杨子恒（研究员）

杨子恒 ( Ziheng Yang )

职 称: 研究员

职 务: 博士生导师

学科类别: 遗传学 贝叶斯统计 生物信息学

2010至今: Director, R.A. Fisher 计算生物学中心，伦敦大学学院

2010至今: R.A. Fisher 统计遗传学教授，遗传进化与环境系，伦敦大学学院

2006: 皇家科学院院士

2001-2010: 统计遗传学教授，生物系，伦敦大学学院

2000-2001: 进化遗传学高级讲师, 生物系, Galton 实验室, 伦敦大学学院

1997-2000:讲师, 生物系, Galton 实验室, 伦敦大学学院.

1995-1997: 博士后, 综合生物学系, 加州大学伯克利分校

1994-1995:博士后, 分子进化与遗传学院, 宾夕法尼亚州立大学.

1993-1994: 博士后，动物科学系, 伦敦自然历史博物馆

1992-1993: 博士后，动物科学系, 剑桥大学.

1992-1997: 讲师，动物科学系，北京农业大学.

1987-1989: 讲师，动物科学系，北京农业大学

遗传学 贝叶斯统计 生物信息学

本研究组从事群体遗传学，统计基因组学，计算生物学方面的研究。主要是开发分析遗传学基因组学数据的统计学方法及计算机软件。大量使用极大似然法，贝叶斯方法，MCMC等计算机模拟算法，并与生物遗传学家合作开展数据分析工作。

1. Z. Yang. 2014. Molecular Evolution: A Statistical Approach, Oxford University Press, in press

2. dos Reis, M., T. Zhu, and Z. Yang. 2014. The impact of the rate prior on Bayesian estimation of divergence times with multiple loci. Systematic Biology submitted

3. Yoder, A. D., L. M. Chan, M. dos Reis, P. A. Larsen, C. R. Campbell, R. Rasolarison, M. Barrett, C. Roos, P. Kappeler, J. P. Bielawski, and Z. Yang. 2014. Molecular evolutionary characterization of a V1R subfamily unique to Strepsirrhine primates. Genome Biology and Evolution, in press

4. dos Reis, M.*, M. J. Donoghue, and Z. Yang. 2014. Neither phylogenomic nor palaeontological data support a Paleogene origin of placental mammals. Biology Letters, in press

5. Leaché AD, Harris RB, Rannala B, Yang Z. 2014. The influence of gene flow on species tree estimation: a simulation study. Systematic Biology

6. Yang Z., and C.E. Rodríguez. 2013. Searching for efficient Markov chain Monte Carlo proposal kernels. Proceedings of the National Academy of Sciences of U.S.A.

7. Rannala B, Yang Z. 2013. Molecular clock dating. pages 68-74 in Princeton Handbook of Evolution (ed. D.A. Baum).

8. dos Reis, M., and Z. Yang. 2013. Why do more divergent sequences produce smaller nonsynonymous/synonymous rate ratios in pairwise sequence comparisons? Genetics

9. Stadler T, Yang Z 2013. Dating phylogenies with sequentially sampled tips. Systematic Biology

10. Zou X-H, Yang Z, Doyle JJ & Ge S. 2013. Multilocus estimation of divergence times and ancestral effective population sizes of Oryza species and implications for the rapid diversification of the genus. New Phytologist

11. Rannala, B, and Yang, Z. 2013. Improved reversible jump algorithms for Bayesian species delimitation. Genetics

12. dos Reis, M., and Z. Yang. 2013. The unbearable uncertainty of Bayesian divergence time estimation. Journal of Systematics and Evolution

13. dos Reis M., Inoue J., Hasegawa M., Asher R., Donoghue P.C., Yang Z. 2012. Phylogenomic data sets provide both precision and accuracy in estimating the timescale of placental mammal evolution. Proc. R. Soc. Lond. B. Biol. Sc

14. Zhai W, Nielsen R, Goldman N, Yang Z. 2012. Looking for Darwin in genomic sequences - validity and success of statistical methods. Molecular Biology and Evolution

15. Zhu T, Yang Z. 2012. Maximum likelihood implementation of an isolation-with-migration model with three species for testing speciation with gene flow. Molecular Biology and Evolution

16. Zhang C, Rannala B, Yang Z. 2012. Robustness of compound Dirichlet priors for Bayesian inference of branch lengths. Systematic Biology

17. Yang Z., Rannala B. 2012. Molecular phylogenetics: principles and practice. Nature Review Genetics

18. Parham, J, Donoghue, P, Bell, C, Calway, T, Head, J, Holroyd, P, Inoue, J, Irmis, R, Joyce, W, Ksepka, D, Patane, J, Smith, N, Tarver, J, van Tuinen, M, Yang, Z, Angielczyk, K, Greenwood, J, Hipsley, C, Louis, J, Makovicky, P, Mueller, J, Smith, K, Theodor, J, Warnock, R and Benton, M, 2012. Systematic Biology

19. Warnock, R.C.M., Z. Yang, and P.C.J. Donoghue. 2012. Exploring uncertainty in the calibration of the molecular clock.

20. Rannala B., Zhu T., Yang Z. 2012. Tail paradox, partial identifiability and influential priors in Bayesian branch length inference. Molecular Biology and Evolution

21. Zhang C., Zhang D.-X., Yang Z. 2011. Evaluation of a Bayesian coalescent method of species delimitation. Systematic Biology

22. Brown RP, Yang Z. 2011. Rate variation and estimation of divergence times using strict and relaxed clocks. BMC Evolutionary Biology

23. Zang, L.-L., X.-H. Zou, F.-M. Zhang, Z. Yang, S. Ge, 2011 Phylogeny and species delimitation of the C-genome diploid species in Oryza. Journal of Systematics and Evolution

24. Groussin M., Pawlowski J., Yang Z. 2011. Bayesian relaxed clock estimation of divergence times in Foraminifera. Molecular Phylogenetics and Evolution,

25. Yoshida I, Sugiura W, Shibata J, Ren F, Yang Z, Tanaka H. 2011. Change of positive selection pressure on HIV-1 envelope gene inferred by early and recent samples

26. dos Reis M, Yang Z. 2011. Approximate likelihood calculation for Bayesian estimation of divergence times. Molecular Biology and Evolution

27. Zhu, T., Y. Hu, Z. Ma, D.-X. Zhang, T. Li, and Z. Yang. 2011. Efficient simulation under a population genetics model of carcinogenesis. Bioinformatics

28. Yang Z., dos Reis M. 2011. Statistical properties of the branch-site test of positive selection. Molecular Biology and Evolution

29. Wilkinson RD, Steiper ME, Soligo C, Martin RD, Yang Z, Tavare S. 2011. Dating primate divergences through an integrated analysis of palaeontological and molecular data. Systematic Biology

分子生物与进化学会会员；系统生物学家协会会员；曾任《遗传学》、《分子生物学与进化》和《分子系统学》等杂志副主编

2010年 晋升为R.A. Fisher 讲座教授

2010年 伦敦动物学会Frink奖

2006年 评选为皇家科学院院士